Modelling & Simulation Associate Principal Scientist

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery,developmentand commercialisation of prescription medicines for some of the world’s most serious disease.

Pharmaceutical Technology and Development (PT&D) is the organisationwithin Operations AstraZenecathat turns brilliant science into medicines that help millions of people.In the Digital ScienceOrganisation(DSO),whichsits withinPT&D,we focus on development of digital strategy, newtoolsand technologies. We work collaboratively with functions,ITand external partners to transform the waywedeliver drug substancesand drug productsTheDSOhas recentlycentralised modellingand simulationskills to create a strategic global team of experts covering a wide range ofmodellingand simulationexpertise, with members based in Gothenburg, Sweden,and Macclesfield.UK.

The role

In this role you will work collaboratively with a variety of scientific specialists and project managers across a global organization to optimally deliver engineering modelling solutions and play a key role in crafting and driving themodellingand simulationstrategy.

Responsibilities:

• Build strong working relationships with team members and colleagues across PT&D to support the application of modelling and simulation

• Work collaboratively withprojects teams and experimentalistwithdifferent backgroundstoidentifymodellingand simulationopportunities,to strategically direct experimentationand to translatepharmaceutical process problems intoappropriate mechanistic/firstprinciples models.

• Coach and upskill process engineers by delivering trainings/workshops and sharing good practices of using modelling and simulation tools inpharmaceutical development.

• Support defining andestablishingmodel/data standards, workflows for modelverification andvalidation, data collection, experiment conditions and sampling, etc.Develop,verify,validate,implementand documentmodellingandsimulationworkflows to be used by the wider scientific community.

• Drive and champion the organizational digital transformationby developing automated,documentedand verifiedworkflows to make simulation tools accessible toa wider community of process engineers,chemistsand pharmacists.

• Keep abreast of global developments in your area by attending relevant events such as conferences, webinars, and workshops and being active member of relevant networks and working groups.

• Ensure access tostate-of-the-arttools and technologies through engaging in pre-competitive collaborative projects, initiatives with academia and software vendors, etc.

Essential skills and qualifications:

• A solid scientific backgroundwith aPhDorMSc/MEngin chemical engineering,physics, chemistry,mathematicsor relatedsubject area,ideally with specialism in process modelling.

• A few years post-graduateindustrialwork experienceinarelevant field.

• A solid knowledge of the science behind process modeland experiencedevelopingandapplying process models for development of industrial products and processes.

• Ability to provide scientific leadership, coaching and mentorship for less experienced scientists and for the widerPT&Dcommunity.

• Ability toselectan appropriate modellingapproach andbuild mathematical models of physical/chemicalphenomenaand solve them usingappropriate codingtools.

• Proven strongexpertisein relevant programming and scripting languages, e.g. Matlab, Python, or similar, and a willingness to learn.

• Experience using simulation tools includinggPROMS,DynoChem,Aspen, AnsysFluent/CFX, Ansys Rocky, etc.

• Strong collaboration, communication, influencing and networking skills

• Cultural awareness

Desirable skills and qualifications:

• Considerableexperience in thepharmaceutical/biopharmaceutical/food/cosmetics and personal care/fast paced consumer goods industry.

• A broad knowledge of process equipment and process technology.

• Ability to proactivelyidentifyandapply novel modelling approaches to deliver value in the development and manufacturing of pharmaceutical drug products

• Postdoc research in relevant modeling and simulation subjects.

• Track recordof scientific publications in themodellingand simulationarea

At AstraZeneca,we’rededicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.There’sno better place to make a difference to medicines,patientsand society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning,growthand development.

Join us in thisgreat opportunity! Apply with your CV and cover letter no later than April 1st2025!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.